Medical Research

Hope Happens Inc

  • Saint Louis, MO
  • www.hopehappens.org

Mission Statement

Hope Happens' mission is to improve the quality of life for individuals with Neurological Disorders by inspiring collaborative research to find cures, providing HOPE to everyone afflicted with or connected to a Neurological Disease.

Main Programs

  1. Hope Center for Neurological Disorders
  2. General Awareness-raising
Service Areas

Self-reported

National

Hope Happens for Neurological Disorders improves the lives of people with neurodegenerative disorders by funding translational research that has the potential to fast-track new treatments and cures. We partner with the Hope Center at Washington University School of Medicine in St. Louis, MO.

ruling year

2005

President of the Board of Directors since 2015

Self-reported

Mr. Steven Wolff

Co Principal Officer since 2015

Self-reported

Peter Hobler

Keywords

Self-reported

neurodegenerative disorders, brain, research, ALS, translational, Alzheimer's, Huntington's Parkinson's, epilepsy, muscular dystrophy, brain and spinal cord injuries

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EIN

20-2523211

Also Known As

Hope Happens for Neurological Disorders

Contact

Cause Area (NTEE Code)

Brain Disorders (H48)

Alliance/Advocacy Organizations (B01)

Fund Raising and/or Fund Distribution (G12)

IRS Filing Requirement

This organization is required to file an IRS Form 990 or 990-EZ.

Programs + Results

How does this organization make a difference?

Overview

Self-reported by organization

Hope Happens for Neurological Disorders brings hope to patients with neurodegenerative diseases such as ALS, Huntington's, MS, Parkinson's, Cerebral Palsy, epilepsy, stroke, brain and spinal cord injury by supporting cutting-edge translational research at the Hope Center for Neurological Disorders.

Programs

Self-reported by organization

What are the organization's current programs, how do they measure success, and who do the programs serve?

Program 1

Hope Center for Neurological Disorders

Hope Happens' main and continuing program objective is to provide funding to the Hope Center for Neurological Disorders-- a collaborative alliance between Hope Happens for Neurological Disorders and Washington University in St. Louis. The laboratories of the Hope Center study a range of nervous system diseases with the common feature of neurodegeneration. The Center encourages collaboration among the multiple departments involved and promotes translational research that can lead to developing treatments and cures for neurodegenerative diseases.

Category

Medical Research

Population(s) Served

Disabled, General or Disability Unspecified

Aging/Elderly/Senior Citizens

None

Budget

$250,000

Program 2

General Awareness-raising

Along with providing funding for the Hope Center, Hope Happens works to raise awareness about neurodegenerative disorders; namely, their impact on and cost to society, and the urgent need to develop treatments and cures. The organization uses social media and educational events to this end.

Category

Health Care

Population(s) Served

None

Budget

Charting Impact

Self-reported by organization

Five powerful questions that require reflection about what really matters - results.

  1. What is the organization aiming to accomplish?
    Our objective is to support collaboration in research and to raise greater awareness of the urgent need for cures. We want to enable Hope Center scientists to work smarter and faster. The goal is to more rapidly understand the fundamental mechanisms of neurodegeneration and neurorepair and to translate this learning into new therapies and cures.

    The need for cures is tremendous - disorders of the nervous system are the most common causes of disability for people of all ages. In the United States alone fifty million people have a permanent neurological disability that limits their daily activities; many are progressive or even fatal. According to Dr. John Morris of Washington University, Alzheimer's disease alone will affect more than 30% of Americans by the age of 80.

    In all of medicine, neurological disorders are probably the biggest threat to our society. The incidence rates of these debilitating illnesses are increasing in numbers because people are living longer. Furthermore, there are no treatments for most of these diseases that delay their onset. We have to increase research spending on all the neurological disorders and look at all the funding sources together in order to move forward.
  2. What are the organization's key strategies for making this happen?
    Hope Happens partners with the Hope Center for Neurological Disorders at Washington University.

    Hope Happens (formerly ALS Hope - the James Maritz/Chris Hobler Foundation) was established in 2004 by Chris Hobler, who saw his diagnosis of ALS in 2001 as an opportunity to lead the fight against all neurodegenerative disorders which afflict many of us, including his grandfather who died of ALS in 1981.

    The Hope Center was established in January 2005 as a partnership between Hope Happens and Washington University School of Medicine, one of the top medical schools in the country for research and patient care.

    The Center's innovative approach combines core laboratory facilities and collaborative sharing of research information, equipment and data. Since 2005 the center has grown from 17 to more than 117 principal investigators. Over 650 scientists from 23 different departments are now working collaboratively to translate research into cures for devastating neurological disorders.

    Dr. Alison Goate, former Medical Director of the Hope Center, commented about recent achievements, “We have a great deal of work to do, but there's also cause for optimism. At this time, there are more clinical trials for new treatments for neurodegenerative disorders than ever before, and many of these new treatments had their origins in studies aimed at understanding the causes of the diseases, which is the type of research the Hope Center promotes."
  3. What are the organization's capabilities for doing this?
    Hope Happens partners with the Hope Center for Neurological Disorders at Washington University. At the Hope Center, we

    1. Provide Core Facilities: Hope Happens provides state-of-the-art core resources and technical expertise so that basic scientific discoveries can be rapidly tested—both through relevant and validated animal models and through other techniques that promise even swifter results.

    2. Fund innovative disease-focused Pilot Projects without the years-long delays typical for other sources of grant funds.

    Hope Happens aims to provide the financial resources the Center needs to develop new treatments and cures for all neurological disorders.
  4. How will they know if they are making progress?
    Hope Happens has supported Pilot Projects at the Hope Center since its inception in 2005. All of the pilot projects lead to clinical trails, federally funded research programs, and/or publications in top-tier scientific journals.

    For more information about past pilot projects go to https://hopecenter.wustl.edu/? page_id=1522.
  5. What have and haven't they accomplished so far?
    Chris Hobler understood that fundamental discoveries about one disease could lead to treatments and cures in others. After eleven years, it has become apparent that this vision is becoming a reality. Researchers at the Center - funded by Hope Happens - already have achieved breakthroughs that show great promise.

    The latest examples are: - Hope Center Scientist Dr. Randall Bateman is leading the first trail to test the prevention of Alzheimer's disease. We believe that the diverse portfolio of drugs and approaches of this trial will accelerate the discovery of an effective treatment for Alzheimer’s.

    -A degenerative disease antibody treatment developed by Dr. David Holtzman’s lab is now moving into a human trial with the help of a company called Abbvie. This is a very exciting development.

    -A gene therapy that slows or stops progression of Parkinson’s disease made its way to clinical trials.

    -Identification of a protein that delays the breakdown of axons, the part of the brain cell that broadcasts nerve impulses to other neurons. Axonal degeneration is related to ALS, Alzheimer’s, Multiple Sclerosis and other neurodegenerative diseases.

    - Past support engendered by Hope Happens helped launch Dr. Timothy Miller’s investigations into curing ALS - investigations that have resulted in a new treatment for the inherited form of ALS that is currently in Phase II Clinical Trials. Currently there are no treatments or cures for ALS, and we are very encouraged about this development.

    - Hope Center scientists Aaron DiAntonio and Jung Eun Shin identified a protein required to regrow injured peripheral nerves. The finding has implications for improving recovery after nerve injury in the extremities. It also opens new avenues of investigation toward triggering nerve regeneration in the central nervous system, notorious for its inability to heal.
Service Areas

Self-reported

National

Hope Happens for Neurological Disorders improves the lives of people with neurodegenerative disorders by funding translational research that has the potential to fast-track new treatments and cures. We partner with the Hope Center at Washington University School of Medicine in St. Louis, MO.

Social Media

Affiliations + Memberships

Association of Fundraising Professionals - Member

Videos

photos



External Reviews

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Financials

Financial information is an important part of gauging the short- and long-term health of the organization.

HOPE HAPPENS INC
Fiscal year: Jan 01-Dec 31

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Operations

The people, governance practices, and partners that make the organization tick.

Hope Happens Inc

Leadership

NEED MORE INFO ON THIS NONPROFIT?

Free: Gain immediate access to the following:
  • Address, phone, website and contact information
  • Forms 990 for 2014, 2014 and 2013
  • Board Chair, Board Co-Chair and Board Members
  • Access to the GuideStar Community
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President of the Board of Directors

Mr. Steven Wolff

Co Principal Officer

Peter Hobler

Governance

BOARD CHAIR

Steve Wolff

Wolff Properties

Term: Jan 2015 -

BOARD LEADERSHIP PRACTICES

GuideStar worked with BoardSource, the national leader in nonprofit board leadership and governance, to create this section, which enables organizations and donors to transparently share information about essential board leadership practices. Self-reported by organization

Yes

BOARD ORIENTATION & EDUCATION

Does the board conduct a formal orientation for new board members and require all board members to sign a written agreement regarding their roles, responsibilities, and expectations?

No

CEO OVERSIGHT

Has the board conducted a formal, written assessment of the chief executive within the past year?

Yes

ETHICS & TRANSPARENCY

Have the board and senior staff reviewed the conflict-of-interest policy and completed and signed disclosure statements in the past year?

Yes

BOARD COMPOSITION

Does the board ensure an inclusive board member recruitment process that results in diversity of thought and leadership?

Yes

BOARD PERFORMANCE

Has the board conducted a formal, written self-assessment of its performance within the past three years?


ORGANIZATIONAL DEMOGRAPHICS

In order to support nonprofits and gain valuable insight for the sector, GuideStar worked with D5—a five-year initiative to advance diversity, equity, and inclusion in philanthropy—in creating a questionnaire. This section is a voluntary questionnaire that empowers organizations to share information on the demographics of who works in and leads organizations. To protect the identity of individuals, we do not display sexual orientation or disability information for organizations with fewer than 15 staff. Any values displayed in this section are percentages of the total number of individuals in each category (e.g. 20% of all Board members for X organization are female).

Gender
Race & Ethnicity
This organization reports that it does not collect this information.
Sexual Orientation

This organization reports that it does not collect this information.

Disability

This organization reports that it does not collect this information.

Diversity Strategies
Yes
We track retention of staff, board, and volunteers across demographic categories
No
We track income levels of staff, senior staff, and board across demographic categories
No
We track the age of staff, senior staff, and board
No
We track the diversity of vendors (e.g., consultants, professional service firms)
No
We have a diversity committee in place
No
We have a diversity manager in place
No
We have a diversity plan
No
We use other methods to support diversity