SILVER2022

Juvenile Bipolar Research Foundation, Inc.

aka JBRF   |   Irvine, CA   |  http://www.jbrf.org

Mission

The Juvenile Bipolar Research Foundation (JBRF) was founded in January 2001. JBRF is dedicated to research to determine the etiology of juvenile - onset bipolar disorder to advance the state of knowledge about this condition so that more effective treatments can be found. JBRF is committed to the development of early diagnostic instruments, thus improving the likelihood for a healthy and productive life for children with bipolar disorder.

Ruling year info

2002

Research Director

Demitri Papolos MD

Main address

17595 Harvard Ave. Suite C-616

Irvine, CA 92614 USA

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EIN

16-1612095

NTEE code info

Pediatrics Research (H98)

Mental Health Disorders (F70)

Diseases, Disorders, Medical Disciplines N.E.C. (G99)

IRS filing requirement

This organization is required to file an IRS Form 990 or 990-EZ.

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Communication

Programs and results

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Our programs

SOURCE: Self-reported by organization

What are the organization's current programs, how do they measure success, and who do the programs serve?

Open Study of the Neurobiological Effects of Intranasal Ketamine in Adults with Bipolar Disorder – F

This is a study designed to provide preliminary data on the therapeutic effects of intranasal ketamine in subjects with a recently reported phenotype of pediatric bipolar disorder that has been titled the ‘Fear of Harm’ (FOH) phenotype. FOH is associated with separation anxiety, aggressive obsessions, and behavioral symptoms that mimic those of post-traumatic stress disorder. Children with FOH often experience thermal discomfort (e.g., feeling hot, excessive sweating) in neutral ambient temperature conditions, as well as no discomfort during exposure to the extreme cold, and alternate noticeably between being excessively hot in the evening and cold in the morning. This putative, heritable phenomenon (a deficit in thermoregulation) - a tendency to generate excessive heat and/or a deficit in heat dissipation results in REM sleep-related problems and parasomnias (night- terrors, sleep-walking, sleep-talking, bruxism, and enuresis), as well as morning sleep inertia. Clinically, FOH is associated with the advent in early childhood of recurrent, vivid, nightmares with themes of pursuit and abandonment. The apparent psychological sequelae of exposure to this frequent, frightening imagery is fear sensitization. A developmental sequence of fear based defensive behaviors arises and includes obsessive bedtime rituals, fear of the dark, separation anxiety, contamination fears, hypervigilance, misperception of neutral stimuli as threatening, reactive aggression in response to limit setting and perceived threat or loss.

Population(s) Served
Parents
Families
People with psychosocial disabilities
People with other disabilities
Academics
Parents
Families
People with psychosocial disabilities
People with other disabilities
Academics
Parents
Families
People with psychosocial disabilities
People with other disabilities
Academics

Bipolar disorder (BD) and, in particular, the ultra-rapid cycling form of the condition most often seen in early-onset cases is typically manifest by severe sleep disturbances in the form of sleep-onset insomnia, sleep inertia, shortened REM latencies, and other arousal disorders of sleep. VNS appears to be an effective and well-tolerated treatment option in prospective, open-label, nonrandomized, observational studies in adult patients with treatment-resistant ultra-rapid cycling BD1, and has been found to provide significantly enhanced antidepressant effects with superior long-term outcomes compared with treatment as usual in a severely ill adult patient population with treatment-resistant depression2.

This project aims to assess the impact of VNS as a non-pharmacological adjunctive therapy in the treatment of bipolar disorder in children ages 6-16. The study will focus on the determination of the efficacy of VNS to improve sleep quality through the correction of early insomnia, RE

Population(s) Served
Children and youth
Children and youth

Where we work

Awards

12148 MHAROA 2011

Combined Federal Campaign (CFC

Our Sustainable Development Goals

SOURCE: Self-reported by organization

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Financials

Juvenile Bipolar Research Foundation, Inc.
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Operations

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Juvenile Bipolar Research Foundation, Inc.

Board of directors
as of 12/02/2022
SOURCE: Self-reported by organization
Board chair

Steven Mattis

Herb Lachman

Department of Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine

Steven Mattis

Department of Neurology at New York Presbyterian-Cornell Medical Center

Demitri Papolos

Department of Psychiatry and Behvioral Sciemces at Albert Einstein College of Medicine

John Cosentino

Ironwood Manufacturing Fund