Juvenile Bipolar Research Foundation, Inc.
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Our programs
What are the organization's current programs, how do they measure success, and who do the programs serve?
Open Study of the Neurobiological Effects of Intranasal Ketamine in Adults with Bipolar Disorder – F
This is a study designed to provide preliminary data on the therapeutic effects of intranasal ketamine in subjects with a recently reported phenotype of pediatric bipolar disorder that has been titled the ‘Fear of Harm’ (FOH) phenotype. FOH is associated with separation anxiety, aggressive obsessions, and behavioral symptoms that mimic those of post-traumatic stress disorder. Children with FOH often experience thermal discomfort (e.g., feeling hot, excessive sweating) in neutral ambient temperature conditions, as well as no discomfort during exposure to the extreme cold, and alternate noticeably between being excessively hot in the evening and cold in the morning. This putative, heritable phenomenon (a deficit in thermoregulation) - a tendency to generate excessive heat and/or a deficit in heat dissipation results in REM sleep-related problems and parasomnias (night- terrors, sleep-walking, sleep-talking, bruxism, and enuresis), as well as morning sleep inertia. Clinically, FOH is associated with the advent in early childhood of recurrent, vivid, nightmares with themes of pursuit and abandonment. The apparent psychological sequelae of exposure to this frequent, frightening imagery is fear sensitization. A developmental sequence of fear based defensive behaviors arises and includes obsessive bedtime rituals, fear of the dark, separation anxiety, contamination fears, hypervigilance, misperception of neutral stimuli as threatening, reactive aggression in response to limit setting and perceived threat or loss.
Open Study of VNS Treatment as an Adjunctive Therapy for Bipolar and Fear of Harm
Bipolar disorder (BD) and, in particular, the ultra-rapid cycling form of the condition most often seen in early-onset cases is typically manifest by severe sleep disturbances in the form of sleep-onset insomnia, sleep inertia, shortened REM latencies, and other arousal disorders of sleep. VNS appears to be an effective and well-tolerated treatment option in prospective, open-label, nonrandomized, observational studies in adult patients with treatment-resistant ultra-rapid cycling BD1, and has been found to provide significantly enhanced antidepressant effects with superior long-term outcomes compared with treatment as usual in a severely ill adult patient population with treatment-resistant depression2.
This project aims to assess the impact of VNS as a non-pharmacological adjunctive therapy in the treatment of bipolar disorder in children ages 6-16. The study will focus on the determination of the efficacy of VNS to improve sleep quality through the correction of early insomnia, RE
Where we work
Awards
12148 MHAROA 2011
Combined Federal Campaign (CFC
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Juvenile Bipolar Research Foundation, Inc.
Board of directorsas of 12/02/2022
Steven Mattis
Herb Lachman
Department of Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine
Steven Mattis
Department of Neurology at New York Presbyterian-Cornell Medical Center
Demitri Papolos
Department of Psychiatry and Behvioral Sciemces at Albert Einstein College of Medicine
John Cosentino
Ironwood Manufacturing Fund